ProClass Protein Family Database | Zendy

Cathy Wu | Zendy; Sailaja Shivakumar | Zendy; Hongzhan Huang | Zendy

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ProClass Protein Family Database

Author(s) -

Cathy Wu,

Sailaja Shivakumar,

Hongzhan Huang

Publication year - 1999

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/27.1.272

Subject(s) - biology , annotation , database , protein family , sequence database , protein structure database , sequence alignment , protein domain , sequence motif , uniprot , computational biology , bioinformatics , genetics , computer science , peptide sequence , gene

ProClass is a protein family database that organizes non-redundant sequence entries into families defined collectively by PROSITE patterns and PIR superfamilies. By combining global similarities and functional motifs into a single classification scheme, ProClass helps to reveal domain and family relationships and classify multi-domain proteins. The database currently consists of more than 120 000 sequence entries, approximately 60% of which is classified into about 3500 families. To maximize family information retrieval, the database provides links to various protein family/domain and structural class databases and contains multiple motif alignments of all PROSITE patterns as well as global alignments of PIR superfamilies. The motif sequences are retrieved from both PIR-International and SWISS-PROT databases, including a large number of new members detected by our GeneFIND family identification system. ProClass can be used to support full-scale genomic annotation, because of its high classification rate. The ProClass database is available for on-line search and record retrieval from our WWW server at http://diana.uthct.edu/proclass.html

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