MITOP: database for mitochondria-related proteins, genes and diseases | Zendy

Curt Scharfe | Zendy; Paolo Zaccaria | Zendy; Konstanze Hoertnagel | Zendy; Michaela Jaksch | Zendy; Thomas Klopstock | Zendy; Roland Lill | Zendy; Holger Prokisch | Zendy; Klaus-Dieter Gerbitz | Zendy; HansWerner Mewes | Zendy; Thomas Meitinger | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

MITOP: database for mitochondria-related proteins, genes and diseases

Author(s) -

Curt Scharfe,

Paolo Zaccaria,

Konstanze Hoertnagel,

Michaela Jaksch,

Thomas Klopstock,

Roland Lill,

Holger Prokisch,

Klaus-Dieter Gerbitz,

HansWerner Mewes,

Thomas Meitinger

Publication year - 1999

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/27.1.153

Subject(s) - biology , caenorhabditis elegans , uniprot , genetics , neurospora crassa , gene , sequence database , homology (biology) , computational biology , database , computer science , mutant

The MITOP database http://websvr.mips.biochem.mpg. de/proj/medgen/mitop/ consolidates information on both nuclear- and mitochondrial-encoded genes and their proteins. The five species files- Saccharomyces cerevisiae, Mus musculus, Caenorhabditis elegans, Neurospora crassa and Homo sapiens -include annotated data derived from a variety of online resources and the literature. A wide spectrum of search facilities is given in the interelated sections 'Gene catalogues', 'Protein catalogues', 'Homologies', 'Pathways and metabolism', and 'Human disease catalogue' including extensive references and hyperlinks for each entry. Precomputed FASTA searches using all the MITOP yeast protein entries and a list of the best EST hits with graphical cluster alignments related to the yeast reference sequence are presented. The MITOP orthologue tables with cross-listing to all the protein entries for each species in the database facilitate investigations into interspecies homology. A program (MITOPROT) is available to identify mitochondrial targeting sequences and graphical depictions of several important mitochondrial processes are included. The 'Human disease catalogue' lists a total of 101 disorders related to mitochondrial protein abnormalities, sorted by clinical criteria and age of onset.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research