Recent developments in the hammerhead ribozyme field | Zendy

Narendra K. Vaish | Zendy; Anilkumar R. Kore | Zendy; F. Eckstein | Zendy

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Recent developments in the hammerhead ribozyme field

Author(s) -

Narendra K. Vaish,

Anilkumar R. Kore,

F. Eckstein

Publication year - 1998

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/26.23.5237

Subject(s) - ribozyme , hammerhead ribozyme , biology , hairpin ribozyme , mammalian cpeb3 ribozyme , computational biology , cleavage (geology) , vs ribozyme , ligase ribozyme , rna , genetics , gene , paleontology , fracture (geology)

Developments in the hammerhead ribozyme field during the last two years are reviewed here. New results on the specificity of this ribozyme, the mechanism of its action and on the question of metal ion involvement in the cleavage reaction are discussed. To demonstrate the potential of ribozyme technology examples of the application of this ribozyme for the inhibition of gene expression in cell culture, in animals, as well as in plant models are presented. Particular emphasis is given to critical steps in the approach, including RNA site selection, delivery, vector development and cassette construction.

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