Long-range interaction between the P2.1 and P9.1 peripheral domains of the Tetrahymena ribozyme | Zendy

Yoshiya Ikawa | Zendy; Hiroshi Ohta | Zendy; Hideaki Shiraishi | Zendy; Takuro Inoue | Zendy

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Long-range interaction between the P2.1 and P9.1 peripheral domains of the Tetrahymena ribozyme

Author(s) -

Yoshiya Ikawa,

Hiroshi Ohta,

Hideaki Shiraishi,

Takuro Inoue

Publication year - 1997

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/25.9.1761

Subject(s) - ribozyme , tetrahymena , biology , vs ribozyme , hairpin ribozyme , genetics , microbiology and biotechnology , rna , gene

The Tetrahymena ribozyme possesses peripheral domains, termed P9.1 and P9.2. They are nonessential in the mechanism of the catalytic reaction but contribute to enhance the catalytic activity of the ribozyme. It has been postulated that P9.1 is capable of forming Watson-Crick base pairings with another peripheral domain, P2.1. We report here the existence of long-range base pairings between the loop regions of these two domains and show that this interaction apparently plays a role in enhancing the catalytic activity of the ribozyme.

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