Intracellular Localization and Unique Conserved Sequences of Three Small Nucleolar RNAs | Zendy

N. Selvamurugan | Zendy; Oscar Joost | Zendy; E. S. Haas | Zendy; James W. Brown | Zendy; Nancy Galvin | Zendy; George L. Eliceiri | Zendy

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Intracellular Localization and Unique Conserved Sequences of Three Small Nucleolar RNAs

Author(s) -

N. Selvamurugan,

Oscar Joost,

E. S. Haas,

James W. Brown,

Nancy Galvin,

George L. Eliceiri

Publication year - 1997

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/25.8.1591

Subject(s) - small nucleolar rna , biology , nucleolus , intron , rna , conserved sequence , genetics , ribosomal rna , gene , flatworm , long non coding rna , cytoplasm , microbiology and biotechnology , peptide sequence , ecology

Three human small nucleolar RNAs (snoRNAs), E1, E2 and E3, were reported earlier that have unique sequences, interact directly with unique segments of pre-rRNA in vivo and are encoded in introns of protein genes. In the present report, human and frog E1, E2 and E3 RNAs injected into the cytoplasm of frog oocytes migrated to the nucleus and specifically to the nucleolus. This indicates that the nucleolar and nuclear localization signals of these snoRNAs reside within their evolutionarily conserved segments. Homologs of these snoRNAs from several vertebrates were sequenced and this information was used to develop RNA secondary structure models. These snoRNAs have unique phylogenetically conserved sequences.

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