The Fission Yeast UVDR DNA Repair Pathway Is Inducible | Zendy

Scott Davey | Zendy; Monica Nass | Zendy; J. V. Ferrer | Zendy; Khalifah Sidik | Zendy; Andrew Eisenberger | Zendy; David L. Mitchell | Zendy; G. A. Frayer | Zendy

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The Fission Yeast UVDR DNA Repair Pathway Is Inducible

Author(s) -

Scott Davey,

Monica Nass,

J. V. Ferrer,

Khalifah Sidik,

Andrew Eisenberger,

David L. Mitchell,

G. A. Frayer

Publication year - 1997

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/25.5.1002

Subject(s) - pyrimidine dimer , schizosaccharomyces pombe , nucleotide excision repair , biology , dna repair , schizosaccharomyces , endonuclease , phosphodiester bond , dna , yeast , dna damage , mutant , base excision repair , microbiology and biotechnology , ap endonuclease , gene , genetics , biochemistry , rna

In addition to nucleotide excision repair (NER), the fission yeast Schizosaccharomyces pombe possesses a UV damage endonuclease (UVDE) for the excision of cyclobutane pyrimidine dimers and 6-4 pyrimidine pyrimidones. We have previously described UVDE as part of an alternative excision repair pathway, UVDR, for UV damage repair. The existence of two excision repair processes has long been postulated to exist in S.pombe, as NER-deficient mutants are still proficient in the excision of UV photoproducts. UVDE recognizes the phosphodiester bond immediately 5'of the UV photoproducts as the initiating event in this process. We show here that UVDE activity is inducible at both the level of uve1+ mRNA and UVDE enzyme activity. Further, we show that UVDE activity is regulated by the product of the rad12 gene.

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