Information transfer from peptide nucleic acids to RNA by template- directed syntheses | Zendy

Jürgen Schmidt | Zendy

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Information transfer from peptide nucleic acids to RNA by template- directed syntheses

Author(s) -

Jürgen Schmidt

Publication year - 1997

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/25.23.4797

Subject(s) - nucleic acid , guanosine , dna , rna , biology , transfer rna , biochemistry , template , oligomer , base pair , nucleotide , ribose , peptide , peptide nucleic acid , nucleic acid methods , nucleic acid analogue , nucleic acid thermodynamics , combinatorial chemistry , base sequence , chemistry , gene , organic chemistry , materials science , enzyme , nanotechnology

Peptide nucleic acids (PNAs) are uncharged analogs of DNA and RNA in which the ribose-phosphate backbone is substituted by a backbone held together by amide bonds. PNAs are interesting as models of alternative genetic systems because they form potentially informational base paired helical structures. A PNA C10 oligomer has been shown to act as template for efficient formation of oligoguanylates from activated guanosine ribonucleotides. In a previous paper we used heterosequences of DNA as templates in sequence-dependent polymerization of PNA dimers. In this paper we show that information can be transferred from PNA to RNA. We describe the reactions of activated mononucleotides on heterosequences of PNA. Adenylic, cytidylic and guanylic acids were incorporated into the products opposite their complement on PNA, although less efficiently than on DNA templates.

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