Reduced RNA polymerase II transcription in extracts of Cockayne syndrome and xeroderma pigmentosum/Cockayne syndrome cells | Zendy

Grigory L. Dianov | Zendy; Jean-François Houle | Zendy; N. Iyer | Zendy; Vilhelm A. Bohr | Zendy; E C Friedberg | Zendy

Open Access

Reduced RNA polymerase II transcription in extracts of Cockayne syndrome and xeroderma pigmentosum/Cockayne syndrome cells

Author(s) -

Grigory L. Dianov,

Jean-François Houle,

N. Iyer,

Vilhelm A. Bohr,

E C Friedberg

Publication year - 1997

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/25.18.3636

Subject(s) - xeroderma pigmentosum , cockayne syndrome , transcription factor ii h , biology , nucleotide excision repair , complementation , rna polymerase ii , transcription (linguistics) , genetics , microbiology and biotechnology , dna repair , gene , gene expression , phenotype , promoter , linguistics , philosophy

The hereditary disease Cockayne syndrome (CS) is a complex clinical syndrome characterized by arrested post-natal growth as well as neurological and other defects. The CSA and CSB genes are implicated in this disease. The clinical features of CS can also accompany the excision repair-defective hereditary disorder xeroderma pigmentosum (XP) from genetic complementation groups B, D or G. The XPB and XPD proteins are subunits of RNA polymerase II (RNAP II) transcription factor IIH (TFIIH). We show here that extracts of CS-A and CS-B cells, as well as those from XP-B/CS cells, support reduced levels of RNAP II transcription in vitro and that this feature is dependent on the state or quality of the template.

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