Targeted expression of Cre recombinase to adipose tissue of transgenic mice directs adipose-specific excision of loxP-flanked gene segments | Zendy

Carrolee Barlow | Zendy; M. Schroeder | Zendy; Julie Lekstrom-Himes | Zendy; Helen Kylefjord | Zendy; ChuXia Deng | Zendy; Anthony WynshawBoris | Zendy; Bruce M. Spiegelman | Zendy; K G Xanthopoulos | Zendy

Open Access

Targeted expression of Cre recombinase to adipose tissue of transgenic mice directs adipose-specific excision of loxP-flanked gene segments

Author(s) -

Carrolee Barlow,

M. Schroeder,

Julie Lekstrom-Himes,

Helen Kylefjord,

ChuXia Deng,

Anthony WynshawBoris,

Bruce M. Spiegelman,

K G Xanthopoulos

Publication year - 1997

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/25.12.2543

Subject(s) - cre recombinase , biology , adipose tissue , enhancer , gene targeting , cre lox recombination , transgene , recombinase , gene , genetically modified mouse , fate mapping , gene expression , microbiology and biotechnology , genetics , recombination , embryonic stem cell , biochemistry

Functional analysis of mammalian genes relies, in part, on targeted mutations generated by homologous recombination in mice. We have developed a strategy for adipose-specific inactivation of loxP-floxed gene segments. Transgenic mice have been established that express Cre recombinase under the control of the adipose-specific aP2 enhancer/promoter. Crossing of the aP2/ Cre mice with any loxP-floxed gene will facilitate its functional analysis in adipose tissue.

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