The / fold family of proteins database and the cholinesterase gene server ESTHER | Zendy

Xavier Cousin | Zendy; Thierry Hôtelier | Zendy; K. Giles | Zendy; P. Lievin | Zendy; JeanPierre Toutant | Zendy; Arnaud Chatonnet | Zendy

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The / fold family of proteins database and the cholinesterase gene server ESTHER

Author(s) -

Xavier Cousin,

Thierry Hôtelier,

K. Giles,

P. Lievin,

JeanPierre Toutant,

Arnaud Chatonnet

Publication year - 1997

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/25.1.143

Subject(s) - biology , gene , hydrolase , enzyme , database , acetylcholinesterase , homology (biology) , homology modeling , genetics , biochemistry , computational biology , computer science

ESTHER (for esterases, alpha/betahydrolase enzyme and relatives) is a database of sequences phylogenetically related to cholinesterases. These sequences define a homogeneous group of enzymes (carboxylesterases, lipases and hormone-sensitive lipases) sharing a similar structure of a central beta-sheet surrounded by alpha-helices. Among these proteins a wide range of functions can be found (hydrolases, adhesion molecules, hormone precursors). The purpose of ESTHER is to help comparison of structures and functions of members of the family. Since the last release, new features have been added to the server. A BLAST comparison tool allows sequence homology searches within the database sequences. New sections are available: kinetics and inhibitors of cholinesterases, fasciculin-acetylcholinesterase interaction and a gene structure review. The mutation analysis compilation has been improved with three-dimensional images. A mailing list has been created.

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