Afut1, a retrotransposon-like element from Aspergillus fumigatus | Zendy

Cécile Neuvéglise | Zendy

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Afut1, a retrotransposon-like element from Aspergillus fumigatus

Author(s) -

Cécile Neuvéglise

Publication year - 1996

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/24.8.1428

Subject(s) - retrotransposon , biology , transposable element , genetics , long terminal repeat , gene , reverse transcriptase , aspergillus fumigatus , rna , genome , microbiology and biotechnology

A repeated DNA sequence used for epidemiological studies of the human opportunistic pathogen Aspergillus fumigatus has been characterized. It is a retroelement of 6914 bp in length, bounded by long terminal repeats of 282 bp, with sequence and features characteristic of retroviruses and retrotransposons. A 5 bp duplication site was found at its borders. This element, designated Afut1, encodes amino acid sequences homologous to the reverse transcriptase, RNase H and endonuclease encoded by the pol genes of retroelements. Comparison of the peptidic sequences with other putative polypeptides of fungal LTR retrotransposons showed that Afut1 is a member of the gypsy group. This is the first report of a transposable element in A.fumigatus. Afut1 is a defective element: the putative coding domains contain multiple stop codons due exclusively to transitions from C:G to T:A.

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