Open AccessThe Use of Non-Uniform Deuterium Labelling ['NMR-Window'] To Study the NMR Structure of a 21mer RNA Hairpin
Author(s) -
András Földesi,
Shun-ichi Yamakage,
Frida Nilsson,
T. V. Maltseva,
Jyoti Chattopadhyaya
Publication year - 1996
Publication title -
nucleic acids research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 9.008
H-Index - 537
eISSN - 1362-4954
pISSN - 0305-1048
DOI - 10.1093/nar/24.7.1187
Subject(s) - biology , labelling , deuterium nmr , nuclear magnetic resonance spectroscopy , deuterium , rna , window (computing) , nuclear magnetic resonance , biochemistry , physics , nuclear physics , gene , operating system , computer science
The first synthesis of a non-uniformly deuterium labelled 21mer RNA is reported using our 'NMR-window' concept, showing its unique application in the unambiguous NMR assignment of the non-exchangeable aromatic and sugar protons.
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