Tissue-Specific Expression of an Anti-ras Ribozyme Inhibits Proliferation of Human Malignant Melanoma Cells | Zendy

Y. Ohta | Zendy; Hiroaki Kijima | Zendy; Toshika Ohkawa | Zendy; Mohammed KashaniSabet | Zendy; Kevin J. Scanlon | Zendy

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Tissue-Specific Expression of an Anti-ras Ribozyme Inhibits Proliferation of Human Malignant Melanoma Cells

Author(s) -

Y. Ohta,

Hiroaki Kijima,

Toshika Ohkawa,

Mohammed KashaniSabet,

Kevin J. Scanlon

Publication year - 1996

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/24.5.938

Subject(s) - biology , ribozyme , melanoma , tyrosinase , microbiology and biotechnology , cancer research , gene expression , oncogene , gene , phenotype , rna , promoter , enzyme , biochemistry , cell cycle

In this study, we have compared the efficacy of a tissue-specific promoter (tyrosinase promoter) with a viral promoter to express anti-ras ribozyme RNA in human melanoma cells. The retroviral vector containing the tyrosinase promoter was superior in its ability to suppress the human melanoma phenotype in vitro as characterized by changes in growth, melanin synthesis, morphology and H-ras gene expression. These data support the use of tissue-specific expression of anti-oncogene ribozymes as a rational therapeutic strategy in human cancers.

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