RNase E processing of essential cell division genes mRNA in Escherichia coli | Zendy

K. Cam | Zendy

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RNase E processing of essential cell division genes mRNA in Escherichia coli

Author(s) -

K. Cam

Publication year - 1996

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/24.15.3065

Subject(s) - ftsz , biology , rnase p , gene , escherichia coli , cell division , genetics , promoter , messenger rna , rnase h , cleavage (geology) , microbiology and biotechnology , gene expression , ribonuclease iii , rna , cell , rna interference , paleontology , fracture (geology)

The ratio of the FtsZ to FtsA proteins determines the correct initiation of cell division in Escherichia coli. The genes for these proteins are contiguous on the chromosome. Although both genes are transcribed from common promoters, the presence of ftsZ-specific promoters, along with differences in the efficiency of translation of their respective mRNAs, contribute to the increased relative expression of ftsZ. We report here that the polycistronic ftsA-ftsZ transcripts are cleaved by RNase E and that this cleavage affects the decay of ftsA and ftsZ mRNA. As a consequence of the cleavage, RNase E also contributes to the differential expression of the two genes.

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