Modelling Extreme Stretching of DNA | Zendy

Anne Lebrun | Zendy; Richard Lavery | Zendy

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Modelling Extreme Stretching of DNA

Author(s) -

Anne Lebrun,

Richard Lavery

Publication year - 1996

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/24.12.2260

Subject(s) - biology , ribbon , helix (gastropod) , dna , base pair , duplex (building) , base (topology) , biophysics , base sequence , crystallography , geometry , genetics , mathematics , ecology , mathematical analysis , chemistry , snail

Molecular modelling with Jumna is used to study extreme stretching of the DNA double helix. The results, which correlate well with recent nanomanipulation experiments, show how the double helix can be extended to twice its normal length before its base pairs break. Depending on the way the duplex is stretched two types of conformation can occur, either an unwound flat ribbon or a narrow fibre with negatively inclined base pairs. The energetics of both types of deformation are similar and existing structures show that at least the flat ribbon form can exist locally under biological conditions.

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