The single pseudouridine residue inEscherichia coli16S RNA is located at position 516 | Zendy

Andrei V. Bakin | Zendy; Jeffrey A. Kowalak | Zendy; James A. McCloskey | Zendy; James Ofengand | Zendy

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The single pseudouridine residue inEscherichia coli16S RNA is located at position 516

Author(s) -

Andrei V. Bakin,

Jeffrey A. Kowalak,

James A. McCloskey,

James Ofengand

Publication year - 1994

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/22.18.3681

Subject(s) - pseudouridine , biology , escherichia coli , transfer rna , rna , ribosomal rna , ribosome , residue (chemistry) , biochemistry , 16s ribosomal rna , genetics , gene

The number and location of pseudouridine residues in Escherichia coli 16S ribosomal RNA has been determined by a combination of direct and indirect methods. Only one residue was found, at position 516. This site is at the 5'-end of one of the three most highly conserved long sequences of this RNA molecule. A number of experimental findings have strongly implicated this loop in the fidelity of codon recognition by A-site bound tRNA. By virtue of its location, we suggest that psi 516 may also play a role in maintaining the fidelity of protein synthesis.

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