Mosaic tile model for tRNA-enzyme recognition | Zendy

Sergey V. Steinberg | Zendy; Lev L. Kisselev | Zendy

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Mosaic tile model for tRNA-enzyme recognition

Author(s) -

Sergey V. Steinberg,

Lev L. Kisselev

Publication year - 1993

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/21.8.1941

Subject(s) - tile , transfer rna , biology , nucleotide , genetics , identity (music) , computational biology , rna , gene , physics , art , acoustics , visual arts

An improved algorithm was elaborated to analyse tRNA interaction with aminoacyl-tRNA synthetase based on analysis of tRNA sequences. The fundamental element defining the interaction between the tRNA and the synthetase is not a single nucleotide but a nucleotide combination named a tile which comprises of a given nucleotide and its neighbours as they are defined by the tertiary structure of the molecule. Informational content of each tile is calculated as its probability to occur exclusively in a set of cognate tRNAs. Based on this algorithm the identity sites of E. coli tRNA(Ala) and tRNA(Gln) were determined. The results are in a good agreement with the biochemical data and provide new information about identity sites of these tRNAs.

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