Cloning. chromosomal localization and expression pattern of the POU domain gene Oct-11 | Zendy

Andrew S. Goldsborough | Zendy; Lyn Healy | Zendy; N G Copeland | Zendy; Debra J. Gilbert | Zendy; Nancy A. Jenkins | Zendy; Keith R. Willison | Zendy; Alan Ashworth | Zendy

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Cloning. chromosomal localization and expression pattern of the POU domain gene Oct-11

Author(s) -

Andrew S. Goldsborough,

Lyn Healy,

N G Copeland,

Debra J. Gilbert,

Nancy A. Jenkins,

Keith R. Willison,

Alan Ashworth

Publication year - 1993

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/21.1.127

Subject(s) - pou domain , biology , gene , genetics , gene duplication , gene family , cloning (programming) , microbiology and biotechnology , gene expression , homeobox , computer science , programming language

POU domain genes encode a family of highly conserved transacting factors that influence the transcriptional activity of several cell type-specific and ubiquitous genes. We have cloned and sequenced cDNAs encoding a novel mouse POU domain protein, Oct-11, that is closely related within the POU domain to the POU class II proteins, Oct-1 and Oct-2. Recombinant Oct-11 protein binds specifically to an octamer sequence in vitro. The Oct-11 gene is expressed during mouse embryogenesis and in the adult thymus and testis. In addition, it is abundant in the myeloma cell line P3/NS-1/1-Ag4.1. We describe the structure of Oct-11 and its chromosomal localization, and discuss the evidence that the POU class II gene family has evolved by duplication and divergence of a common ancestral gene.

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