Characterization of a novel T lymphocyte protein which binds to a site related to steroid/thyroid hormone receptor response elements in the negative regulatory sequence of the human immunodeficiency virus long terminal repeat | Zendy

Kim Orchard | Zendy; Georgina Lang | Zendy; Mary Collins | Zendy; D.S. Latchman | Zendy

Open Access

Characterization of a novel T lymphocyte protein which binds to a site related to steroid/thyroid hormone receptor response elements in the negative regulatory sequence of the human immunodeficiency virus long terminal repeat

Author(s) -

Kim Orchard,

Georgina Lang,

Mary Collins,

D.S. Latchman

Publication year - 1992

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/20.20.5429

Subject(s) - biology , sequence (biology) , long terminal repeat , consensus sequence , receptor , human immunodeficiency virus (hiv) , steroid hormone , thyroid hormone receptor , hormone , peptide sequence , binding site , virology , biochemistry , gene , gene expression

We have previously identified a T lymphocyte protein which binds to a site within the LTR of the human immunodeficiency virus type 1 (HIV-1) and exerts an inhibitory effect on virus gene expression. The palindromic site (site B) recognized by this protein is related to the palindromic binding sites of members of the steroid/thyroid hormone receptor family. Here we characterize the T cell protein binding to this site as a 100 kD protein which is most abundant in T cells and which binds to site B as a 200 kD complex. This protein is distinct from other members of the steroid/thyroid hormone receptor family including the COUP protein which has a closely related DNA binding specificity.

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