On the statistical significance of primary structural features found in DNA-protein interaction sites | Zendy

G. W. Dykes | Zendy; Robert A. Bambara | Zendy; Kenneth J. Marians | Zendy; Ray Wü | Zendy

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On the statistical significance of primary structural features found in DNA-protein interaction sites

Author(s) -

G. W. Dykes,

Robert A. Bambara,

Kenneth J. Marians,

Ray Wü

Publication year - 1975

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/2.3.327

Subject(s) - biology , dna , sequence (biology) , genetics , repeated sequence , computational biology , dna sequencing , evolutionary biology , genome , gene

Probabilities of occurrence for a number of the symmetries and other sequence regularities found in DNA-protein interaction site sequences have been calculated for segments of random DNA sequence. Results show that many of the symmetrical and repetitive features seen in these interaction sites are likely to have occured by chance. Other features are so unlikely to have occurred by chance that they are probably involved in the DNA-protein interaction processes.

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