Study of the role of the acceptor stem in the interactions between tRNAs and aminoacyl-tRNA synthetases | Zendy

Jacques Bonnet | Zendy; N. Befort | Zendy; C Bollack | Zendy; Franco Fasiolo | Zendy; JeanPierre Ebel | Zendy

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Study of the role of the acceptor stem in the interactions between tRNAs and aminoacyl-tRNA synthetases

Author(s) -

Jacques Bonnet,

N. Befort,

C Bollack,

Franco Fasiolo,

JeanPierre Ebel

Publication year - 1975

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/2.2.211

Subject(s) - aminoacylation , transfer rna , biology , aminoacyl trna synthetase , biochemistry , affinities , amino acyl trna synthetases , nucleotide , genetics , rna , gene

Several studies have clearly demonstrated that the end of the acceptor stem was a very important area determining the aminoacylation properties of tRNAs. However the attempts to measure the contribution of this region to the binding of tRNAs to aminoacyl-tRNA synthetases have led to contradictory results. We report here the stepwise degradation of yeast tRNA-Phe and tRNA-Val from their 3' terminus, up to the seventh nucleotide : the affinity of each of the degraded-tRNA for their cognate aminoacyl-tRNA synthetase was compared to that of intact tRNA and it was found that these affinities are not significantly decreased when compared to those of the intact tRNAs.

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