CD studies of conformational changes of DNA upon photosensitized UV-irradiation at 313 nm | Zendy

H. Lang | Zendy

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CD studies of conformational changes of DNA upon photosensitized UV-irradiation at 313 nm

Author(s) -

H. Lang

Publication year - 1975

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/2.2.179

Subject(s) - pyrimidine dimer , thymine , biology , dna , irradiation , helix (gastropod) , pyrimidine , conformational change , photochemistry , acetophenone , biophysics , stereochemistry , biochemistry , dna damage , chemistry , ecology , physics , snail , nuclear physics , catalysis

The role of thymine dimerization for previously reported U.V. induced conformational changes has been proved using acetophenone as sensitizer for the specific thymine dimerization upon irradiation at 313 nm. CD results demonstrate that formation of pyrimidine dimers cause typical conformational changes of the DNA B helix as observed on irradiation at 254 nm. Thus the primary role of adenine photoproducts may be excluded.

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