Selenium induces changes in the selenocysteine tRNA[Ser]Secpopulation in mammalian cells | Zendy

Dolph L. Hatfield | Zendy; Byeong J. Lee | Zendy; Lori L. Hampton | Zendy; Alan M. Diamond | Zendy

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Selenium induces changes in the selenocysteine tRNA^[Ser]Secpopulation in mammalian cells

Author(s) -

Dolph L. Hatfield,

Byeong J. Lee,

Lori L. Hampton,

Alan M. Diamond

Publication year - 1991

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/19.4.939

Subject(s) - selenocysteine , biology , selenium , transfer rna , glutathione peroxidase , biochemistry , population , peroxidase , microbiology and biotechnology , glutathione , enzyme , rna , gene , cysteine , chemistry , demography , organic chemistry , sociology

Two isoacceptors of selenocysteine tRNA[Ser]Sec are present in higher vertebrates which are responsible for donating selenocysteine to protein. One such selenocysteine containing protein, glutathione peroxidase, requires selenium for its translation and transcription. Since tRNA[Ser]Sec is a critical component of the glutathione peroxidase translational machinery, the levels and distributions of its isoacceptors were examined from both human and rat cells grown in chemically defined media with and without selenium. Not only did the level of the selenocysteine tRNA[Ser]Sec population increase approximately 20% in cells grown in the presence of selenium, but the distributions of the two isoacceptors also changed relative to each other.

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