Expression of adult and tadpole specific globin genes fromXenopus laevisin transgenic mice | Zendy

Niall Dillon | Zendy; George Kollias | Zendy; Frank Grosveld | Zendy; Jeffrey G. Williams | Zendy

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Expression of adult and tadpole specific globin genes fromXenopus laevisin transgenic mice

Author(s) -

Niall Dillon,

George Kollias,

Frank Grosveld,

Jeffrey G. Williams

Publication year - 1991

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/19.22.6227

Subject(s) - biology , xenopus , tadpole (physics) , gene , globin , transgene , microbiology and biotechnology , genetically modified mouse , gene expression , embryo , beta (programming language) , genetics , physics , particle physics , computer science , programming language

Transgenic mice were generated which carried the adult alpha and beta-globin genes and the major tadpole specific beta-globin gene of Xenopus laevis. The adult specific alpha and beta genes were found to express in erythroid tissues in adult mice, while the major tadpole specific beta gene (beta T1) was expressed in blood from 12.5 day embryos. The pattern of expression of the beta T1 gene during mouse development was consistent with its being regulated as an embryonic globin gene in the mouse. This observation suggests that some of the factors mediating globin switching have been conserved during the evolution of modern amphibia and mammals and raises interesting questions concerning the evolution of vertebrate globin gene switching.

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