1H NMR of 5′CGCGTATATACGCG3′, a duplex and a four-membered loop | Zendy

Deborah A. Kallick | Zendy; David E. Wemmar | Zendy

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₁H NMR of 5′CGCGTATATACGCG3′, a duplex and a four-membered loop

Author(s) -

Deborah A. Kallick,

David E. Wemmar

Publication year - 1991

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/19.21.6041

Subject(s) - duplex (building) , cruciform , biology , deoxyribonucleotide , loop (graph theory) , dna , sequence (biology) , nuclear magnetic resonance spectroscopy , crystallography , oligonucleotide , nuclear magnetic resonance , physics , genetics , materials science , combinatorics , chemistry , mathematics , composite material

The deoxyribonucleotide 5'CGCGTATATACGCG3' was synthesized and studied by NMR methods. This short, fully palindromic duplex also forms a hairpin under certain conditions described within. As such, it is considered to be a model for cruciform formation. We show that this sequence forms a four-membered loop and a duplex in solution. The duplex is shown to be a normal, B-DNA like helix, while the hairpin is shown to be a four-membered ATAT loop.

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