Inhibition of SV40 gene expression by microinjected sma antisense RNA and DNA molecules | Zendy

M. Graessmann | Zendy; George Michaels | Zendy; Birgit M.M. van den Berg | Zendy; A. Graessmann | Zendy

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Inhibition of SV40 gene expression by microinjected sma antisense RNA and DNA molecules

Author(s) -

M. Graessmann,

George Michaels,

Birgit M.M. van den Berg,

A. Graessmann

Publication year - 1991

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/19.1.53

Subject(s) - biology , microbiology and biotechnology , dna , gene , gene expression , rna , antisense rna , sma* , genetics , sense (electronics) , engineering , mathematics , combinatorics , electrical engineering

We tested the impact of antisense RNA and DNA molecules on SV40 gene expression by microinjection into TC7 cells. Short antisense stretches, complementary to either hairpin or loop structures on the T antigen mRNA, inhibited T antigen synthesis. In contrast, full-length antisense RNA and DNA molecules did not effect T antigen synthesis.

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