M.Smal is an N4-methylcytosine specific DNA-methylase | Zendy

Saulius Klimašauskas | Zendy; Dana Steponavičiene | Zendy; Z. Manelienė | Zendy; M. Petrušyté | Zendy; Viktoras Butkus | Zendy; A. Janulaitis | Zendy

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M.Smal is an N4-methylcytosine specific DNA-methylase

Author(s) -

Saulius Klimašauskas,

Dana Steponavičiene,

Z. Manelienė,

M. Petrušyté,

Viktoras Butkus,

A. Janulaitis

Publication year - 1990

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/18.22.6607

Subject(s) - 5 methylcytosine , biology , cytosine , methyltransferase , dna , serratia marcescens , restriction enzyme , methionine , microbiology and biotechnology , endonuclease , dna methyltransferase , enzyme , biochemistry , methylation , dna methylation , escherichia coli , amino acid , gene , gene expression

An enzymatic activity rendering DNA immune to the action of the Smal restriction endonuclease in the presence of S-adenosyl-L-methionine has been detected in Serratia marcescens Sb. This methylase, M.Smal, modifies the second cytosine residue of the substrate sequence CCCGGG yielding N4-methylcytosine.

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