Solid-phase synthesis of H-Phe-Tyr-(pATAT)-NH2: a nucleopeptide fragment from the nucleoprotein of bacteriophage øX174 | Zendy

C.M. Dreef-Tromp | Zendy; E. M. A. van Dam | Zendy; Hans van den Elst | Zendy; G. A. VAN DER MAREL | Zendy; Jacques H. van Boom | Zendy

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Solid-phase synthesis of H-Phe-Tyr-(pATAT)-NH₂: a nucleopeptide fragment from the nucleoprotein of bacteriophage øX174

Author(s) -

C.M. Dreef-Tromp,

E. M. A. van Dam,

Hans van den Elst,

G. A. VAN DER MAREL,

Jacques H. van Boom

Publication year - 1990

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/18.22.6491

Subject(s) - biology , bacteriophage , nucleoprotein , fragment (logic) , solid phase synthesis , fluoride , group (periodic table) , phase (matter) , dna , stereochemistry , genetics , microbiology and biotechnology , biochemistry , escherichia coli , gene , organic chemistry , peptide , chemistry , inorganic chemistry , computer science , programming language

The preparation of the nucleopeptide H-Phe-Tyr-(pATAT)-NH2 could be realized via a solid phase phosphitetriester approach and by using the protected protecting group 2-(tert-butyldiphenylsilyoxymethyl)-benzoyl for the masking of the N6-amino function of deoxyadenosine. The latter protecting group can be removed under mild conditions with fluoride ion.

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