Trans-splicing of pre-MRNA is predicted to occur in a wide range of organisms including vertebrates | Zendy

Thomas Dandekar | Zendy; Peter R. Sibbald | Zendy

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Trans-splicing of pre-MRNA is predicted to occur in a wide range of organisms including vertebrates

Author(s) -

Thomas Dandekar,

Peter R. Sibbald

Publication year - 1990

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/18.16.4719

Subject(s) - rna splicing , biology , trans splicing , alternative splicing , genetics , false positive paradox , computational biology , rna , gene , messenger rna , machine learning , computer science

Several known trans-splicing RNA structures were used to define a canonical trans-splicing structure which was then used to perform a computer search of the EMBL nucleotide database. In addition to most known trans-splicing structures, many putative new trans-splicing sites were detected. These were found in a broad range of organisms including the vertebrates. Control experiments indicate that the search predicts known false positives at a rate of only 20%. Trans-splicing may therefore be a very wide-spread phenomenon.

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