The nucleotide sequence of the cDNA encoding a chickenDeformedfamily homeobox gene,Chox-Z | Zendy

Hiroshi Sasaki | Zendy; Atsushi Kuroiwa | Zendy

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The nucleotide sequence of the cDNA encoding a chickenDeformedfamily homeobox gene,Chox-Z

Author(s) -

Hiroshi Sasaki,

Atsushi Kuroiwa

Publication year - 1990

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/18.1.184

Subject(s) - biology , homeobox , genetics , nucleic acid sequence , complementary dna , gene , sequence (biology) , nucleotide , microbiology and biotechnology , gene expression

1. Graham,A., Papalopulu.N., McVey.J.H., Tuddenham,E.G.D. and Krumlauf,R. (1988) Genes and Dev. 2, 1424-1438. 2. Featherstone.M.S., Baron.A., Gaunt,S.J., Mattei,M.-G. and Duboule.D. (1988) Proc. Natl. Acad. Sci. USA 85, 4760-4764. 3. Galliot.B., Dolle,P., Vigneron,M., Featherstone.M.S., Baron.A. and Duboule,D. (1989) Development 107, 343-359. 4. Harvey,R.P., Tabin.C.J. and Melton.D.A. (1986) EMBOJ. 5, 1237-1244. 5. Regulski.M., McGinnis.N., Chadwick.R. and McGinnis,W. (1987) EMBO J. 6, 767-777. cDNA clones encoding a chicken Deformed (Dfd) family homeobox gene, Chox-Z, were isolated from chicken 4 day embryo cDNA library using a chicken genomic DNA fragment containing Chox-Z homeobox as a probe (Kuroiwa in preparation). The cDNA encodes a protein of 245 amino acids. The homeodomain of this protein (underlined) reveals strong homology with those of vertebrates Dfd family homeobox genes, Hox-2.6 (98%) (1), Hox-5.1 (93%) (2), Hox-1.4 (93%) (3), Xhox-IA (95%) (4) and Dfd (88%) (5). The entire Chox-Z protein shows homology with Hox-2.6 (66%) and Xhox-IA (63%) proteins. First 22 nucleotides just upstream from the transcriptional initiation codon have strong homology with corresponding region of Hox-2.6 (86%).

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