A comparison of snRNP-associated Sm-autoantigens: human N, rat N and human B/B′ | Zendy

Claudia Schmauss | Zendy; George McAllister | Zendy; Yasuo Ohosone | Zendy; John A. Hardin | Zendy; Michael R. Lerner | Zendy

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A comparison of snRNP-associated Sm-autoantigens: human N, rat N and human B/B′

Author(s) -

Claudia Schmauss,

George McAllister,

Yasuo Ohosone,

John A. Hardin,

Michael R. Lerner

Publication year - 1989

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/17.4.1733

Subject(s) - biology , complementary dna , snrnp , microbiology and biotechnology , amino acid , peptide sequence , open reading frame , blot , epitope , southern blot , gene , rna , genetics , antibody , rna splicing

N is a tissue-specific, Sm-epitope bearing, snRNP-associated protein found predominantly in brain. The cDNA sequence encoding human N is compared to those for rat N and human B/B'. The amino acid sequences of human and rat N are 100% conserved. Although the amino acid sequences of N and B/B' are very similar to each other, B/B' contains 50 amino acids which are not present in N. On Northern blots the cDNAs encoding N and B/B' recognize two different RNA species. A comparison of the codon usage, as specified by the open reading frames of N and B/B' as well as results from Southern blots, show that N and B/B' are derived from different genes.

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