DNA duplex with the potential to change handedness after every half a turn | Zendy

Samir K. Brahmachari | Zendy; Rakesh K. Mishra | Zendy; Rajesh Bagga | Zendy; N. Ramesh | Zendy

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DNA duplex with the potential to change handedness after every half a turn

Author(s) -

Samir K. Brahmachari,

Rakesh K. Mishra,

Rajesh Bagga,

N. Ramesh

Publication year - 1989

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/17.18.7273

Subject(s) - biology , duplex (building) , z dna , turn (biochemistry) , dna , base pair , conformational change , genetics , sequence (biology) , helix (gastropod) , right handed , base sequence , crystallography , biophysics , biochemistry , paleontology , physics , chemistry , snail , nuclear physics , neutrino

Polymorphic forms of the DNA duplex with long stretches of structural monotony are known. Several alternating purine-pyrimidine sequences have been shown to adopt left-handed Z-conformation. We report a DNA sequence d(CGCGCGATCGAT)n exhibiting alternating right-handed B and left-handed Z helical conformation after every half a turn. Further, this unusual conformation with change in handedness after every six base pairs was induced at physiological superhelical density.

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