A novel germ-line JKtranscript starting immediately upstream of JK1 | Zendy

Lise Leclercq | Zendy; P. Butkeraitis | Zendy; Michael Reth | Zendy

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A novel germ-line J_Ktranscript starting immediately upstream of J_K1

Author(s) -

Lise Leclercq,

P. Butkeraitis,

Michael Reth

Publication year - 1989

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/17.17.6809

Subject(s) - biology , germ , upstream (networking) , line (geometry) , genetics , germline , computational biology , microbiology and biotechnology , gene , telecommunications , computer science , geometry , mathematics

Germ-line transcripts of the immunoglobulin (Ig) and T cell receptor loci are thought to be involved in the control of V gene rearrangement by rendering these loci accessible to the recombinases. We have analyzed the transcriptional activity of germ-line K alleles in two bone marrow-derived Abelson-murine leukemia virus transformed pre-B cells: 300-19, a null cell line, and P8 a mu-producing line. We found a novel germ-line JK transcript starting immediately upstream of JK1 and spliced to CK. The potential role of this transcript in the opening of the Ig K locus as well as in the ordered usage of JK segments is discussed.

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