Differential repair of UV damage inSaccharomyces cerevisiae | Zendy

Carrol Terleth | Zendy; C.A. van Sluis | Zendy; P. van de Putte | Zendy

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Differential repair of UV damage inSaccharomyces cerevisiae

Author(s) -

Carrol Terleth,

C.A. van Sluis,

P. van de Putte

Publication year - 1989

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/17.12.4433

Subject(s) - biology , saccharomyces cerevisiae , locus (genetics) , pyrimidine dimer , mutant , genetics , eukaryote , mating type , saccharomyces , dna repair , gene , genome

Preferential repair of UV-induced damage is a phenomenon by which mammalian cells might enhance their survival. This paper presents the first evidence that preferential repair occurs in the lower eukaryote Saccharomyces cerevisiae. Moreover an unique approach is reported to compare identical sequences present on the same chromosome and only differing in expression. We determined the removal of pyrimidine dimers from two identical alpha-mating type loci and we were able to show that the active MAT alpha locus is repaired preferentially to the inactive HML alpha locus. In a sir-3 mutant, in which both loci are active this preference is not observed.

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