An embryonic DNA-binding protein specific for a region of the human IFN 1, promoter | Zendy

Allison Haggarty | Zendy; Patrice André | Zendy; Gary D. Paterno | Zendy; Luc Daigneault | Zendy; Daniel Skup | Zendy

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An embryonic DNA-binding protein specific for a region of the human IFN 1, promoter

Author(s) -

Allison Haggarty,

Patrice André,

Gary D. Paterno,

Luc Daigneault,

Daniel Skup

Publication year - 1988

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/16.22.10575

Subject(s) - biology , interferon , microbiology and biotechnology , cellular differentiation , dna , dna binding protein , gene , psychological repression , promoter , nuclear protein , binding site , embryonic stem cell , embryonal carcinoma , interferon regulatory factors , transcription factor , genetics , gene expression

Embryonal carcinoma (EC) cells are unable to make interferon in response to inducing agents. This block disappears after differentiation. We have found that nuclear extracts from undifferentiated P19 EC cells contain a DNA-binding activity which specifically recognizes a region within the human interferon-beta 1 promoter. This activity is absent from differentiated cell types, both of EC and non-EC origin. The binding of the factor in undifferentiated EC cells leads to dramatic changes in the overall protein binding pattern of the interferon promoter as compared with differentiated cells, and may be responsible for repression of the endogenous interferon-beta gene prior to differentiation.

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