Open AccessThe yeastADR6gene encodes homopolymeric amino acid sequences and a potential metal-binding domain
Author(s) -
Patrick J. O׳Hara,
Heidi Horowitz,
Greg Eichinger,
Elton T. Young
Publication year - 1988
Publication title -
nucleic acids research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 9.008
H-Index - 537
eISSN - 1362-4954
pISSN - 0305-1048
DOI - 10.1093/nar/16.21.10153
Subject(s) - biology , yeast , gene , genetics , domain (mathematical analysis) , amino acid , saccharomyces cerevisiae , peptide sequence , biochemistry , mathematical analysis , mathematics
The ADR6 gene of Saccharomyces cerevisiae has an open reading frame which could encode a polypeptide of 1314 amino acids. The predicted mRNA encodes a protein with homopolymeric stretches of asparagine and threonine, particularly near its amino terminus and contains additional sequences consisting of polyglutamine repeats. The predicted protein also contains a potential metal binding (Cys)4-type finger near its carboxy-terminus. An ADR6/beta-galactosidase fusion protein was predominantly nuclear in location, consistent with its role as an activator of ADH2 transcription.