Isolation and mapping of a polymorphic DNA sequence (cMCOD13) on chromosome 3[D3S44] | Zendy

Yusuke Nakamura | Zendy; M. Carlson | Zendy; P. O’Connell | Zendy; M. Leppert | Zendy; G.M. Lathrop | Zendy; Jean-Marc Lalouel | Zendy; R. White | Zendy

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Isolation and mapping of a polymorphic DNA sequence (cMCOD13) on chromosome 3[D3S44]

Author(s) -

Yusuke Nakamura,

M. Carlson,

P. O’Connell,

M. Leppert,

G.M. Lathrop,

Jean-Marc Lalouel,

R. White

Publication year - 1988

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/16.19.9356

Subject(s) - biology , genetics , dna , isolation (microbiology) , sequence (biology) , chromosome , dna sequencing , computational biology , evolutionary biology , gene , bioinformatics

POLYMORPHISM: PvuII identifies >10 allelic VNTR polymorphisms with bands between 4.0 and 10.0 kb. TaqI, Rsal Mspl and Pstl identify the same VNTR polymorphism. FREQUENCY; With PvuII, 85 % heterozygosity was observed in 97 unrelated Caucasians. NOT POLYMORPHIC FOR; Bglll CHROMOSOMAL LOCALIZATION: MCOD13 has been assigned to chromosome 3 by linkage analysis (2) with loci (APOD) known to span this chromosome(3). MENDELIAN INHERITANCE: Co-dominant segregation of the Hinfl RFLP was observed in 49 three generation families. PROBE AVAILABILITY: Freely available (contact Y.N.) or will be available from ATCC. OTHER COMMENTS: RFLPs were observed after competitive hybridization with total human DNA. REFERENCES: 1. Y. Nakamura et al., submitted 2. G.M. Lathrop et al., Am. J. Hum. Genet. 12:482-498 (1985) 3. D. Drayna et al., DNA, £:194-204 (1987)

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