Purification and characterization of DNA methyltransferases fromNeisseria gonorrhoeae | Zendy

Andrzej Piekarowicz | Zendy; R Yuan | Zendy; Daniel C. Stein | Zendy

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Purification and characterization of DNA methyltransferases fromNeisseria gonorrhoeae

Author(s) -

Andrzej Piekarowicz,

R Yuan,

Daniel C. Stein

Publication year - 1988

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/16.13.5957

Subject(s) - biology , methyltransferase , neisseria gonorrhoeae , cytosine , dna , nuclease , genetics , microbiology and biotechnology , methylation

Three DNA methyltransferases, M.NgoAI, and M.NgoBI and M.NgoBII, free of any nuclease activities were isolated from Neisseria gonorrhoeae strains WR220 and MUG116 respectively. M.NgoAI recognizes the sequence 5' GGCC 3' and methylates the first 5' cytosine on both strands. M.NgoBI and M.NgoBII recognize 5' TCACC 3' and 5' GTAN5CTC 3' respectively. M.NgoBII methylates cytosine on only one strand to produce 5' GTAN5mCTC 3'.

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