A novel effect of EGF on mRNA stability | Zendy

Yoshihiro Jinno | Zendy; Glenn Merlino | Zendy; I Pastan | Zendy

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A novel effect of EGF on mRNA stability

Author(s) -

Yoshihiro Jinno,

Glenn Merlino,

I Pastan

Publication year - 1988

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/16.11.4957

Subject(s) - biology , epidermal growth factor , messenger rna , receptor , microbiology and biotechnology , phorbol , gene expression , epidermal growth factor receptor , gene , signal transduction , protein kinase c , biochemistry

Expression of the epidermal growth factor (EGF) receptor gene is stimulated by EGF and the phorbol ester, 4 beta-phorbol 12-myristate 13-acetate (PMA). PMA elevates EGF receptor mRNA levels in human KB epidermoid carcinoma cells, but does not significantly affect the half-life of this mRNA when its decay is examined after the addition of actinomycin D. In contrast, EGF greatly prolongs the half-life of EGF receptor mRNA suggesting a possible mechanism for the stimulatory effect of EGF on EGF receptor mRNA levels. EGF also stabilizes beta-tubulin and beta-actin mRNAs but has very little effect on the degradation of total mRNA.

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