The action of a water-soluble carbodiimide on adenosine-5'-polyphosphates | Zendy

Kam-mui Eva Ng | Zendy; Leslie E. Orgel | Zendy

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The action of a water-soluble carbodiimide on adenosine-5'-polyphosphates

Author(s) -

Kam-mui Eva Ng,

Leslie E. Orgel

Publication year - 1987

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/15.8.3573

Subject(s) - carbodiimide , polyphosphate , adenosine , hydrolysis , aqueous solution , biology , biochemistry , adenosine monophosphate , phosphate , chemistry , organic chemistry

When aqueous solutions of adenosine-5'-mono-, di-, or triphosphates are treated with a water soluble carbodiimide the major product is the expected diadenosine-5'-5'-polyphosphate. The yields of these pyrophosphates are greatly increased in the presence of the Mg2+ ion. Adenosine-5'-tetraphosphate behaves differently. The major product is adenosine-5'-monophosphate. We believe that this hydrolysis occurs via a cyclic trimetaphosphate intermediate.

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