Oligodeoxyribonucleotides containing 1, 3-propanediol as nucleoside substitute | Zendy

Frank Seela | Zendy; Klaus Kaiser | Zendy

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Oligodeoxyribonucleotides containing 1, 3-propanediol as nucleoside substitute

Author(s) -

Frank Seela,

Klaus Kaiser

Publication year - 1987

Publication title -

nucleic acids research

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/15.7.3113

Subject(s) - phosphodiester bond , phosphoramidite , propanediol , biology , nucleoside , oligonucleotide , moiety , residue (chemistry) , stereochemistry , biochemistry , deoxyadenosine , dna , rna , chemistry , organic chemistry , gene

1,3-Propanediol was protected with one dimethoxytrityl residue and converted into the methoxy- and cyanoethoxyphosphoramidites 2a and 2b, respectively. Solid-phase oligonucleotide synthesis, employing the phosphoramidite 2a resulted in the dodecamers d(CGCGAATTCGCG) (6-9), in which dA or dT residues were replaced by 1,3-propanediol. These oligomers showed a high tendency to form hairpins. Their phosphodiester bonds between the 3'-position of a nucleoside and the propanediol moiety was not cleaved by snake venom phosphodiesterase.

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