Open AccessThe mRNA and RNA-copy pseudogenes encoding TM30nm, a human cytoskdetal tropomyosin
Author(s) -
Alexander R. MacLeod,
C. Houlker,
Fernando C. Reinach,
K Talbot
Publication year - 1986
Publication title -
nucleic acids research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 9.008
H-Index - 537
eISSN - 1362-4954
pISSN - 0305-1048
DOI - 10.1093/nar/14.21.8413
Subject(s) - tropomyosin , biology , pseudogene , messenger rna , microbiology and biotechnology , gene , alternative splicing , rna splicing , rna , gene expression , genetics , actin , genome
We have determined the sequence of a 2.5 kb mRNA in human fibroblasts encoding a 248 amino acid cytoskeletal tropomyosin. The protein product of this mRNA is TM30nm, one of five tropomyosin-like proteins in human fibroblasts. The structural gene encoding this mRNA can also produce a 1.3 kb mRNA encoding a 285 amino acid skeletal muscle alpha-tropomyosin by tissue-specific alternative mRNA splicing. However, the multiple RNA-copy pseudogenes of this gene family are derived largely if not exclusively from transcripts processed according to the pattern observed in non-muscle cells.
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