The involvement of histone H1° in chromatin structure | Zendy

Joëlle Roche | Zendy; JeanLuc Girardet | Zendy; Claude Gorka | Zendy; JeanJacques Lawrence | Zendy

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The involvement of histone H1° in chromatin structure

Author(s) -

Joëlle Roche,

JeanLuc Girardet,

Claude Gorka,

JeanJacques Lawrence

Publication year - 1985

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/13.8.2843

Subject(s) - micrococcal nuclease , chromatin , histone h1 , biology , histone , dna , biophysics , nuclease , histone code , nucleosome , biochemistry

Micrococcal nuclease digestion and light scattering are used to compare native chromatins with various histone H1[0] contents. The experimental data show that the higher the H1[0] content, the greater the ability to form compact structures with increasing ionic strength, and the lower the DNA accessibility to micrococcal nuclease. On the contrary, reconstituted samples from H1-depleted chromatin and pure individual H1 fractions behave in such a way that samples reconstituted with pure H1 degree give rise to a looser structure, more accessible to nuclease than samples reconstituted with H1-1. This contradiction suggests that the effect of H1o on chromatin structure must originate from the interaction of this histone with other components in native chromatin among which other histone H1 subfractions are good candidates.

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