The genomic organisation and nucleotide sequence of the HLA-SB(DP) alpha gene | Zendy

Simon K. Lawrance | Zendy; Hriday K. Das | Zendy; Julian Pan | Zendy; Sherman M. Weissman | Zendy

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The genomic organisation and nucleotide sequence of the HLA-SB(DP) alpha gene

Author(s) -

Simon K. Lawrance,

Hriday K. Das,

Julian Pan,

Sherman M. Weissman

Publication year - 1985

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/13.20.7515

Subject(s) - haven , library science , biology , classics , genetics , genealogy , history , computer science , combinatorics , mathematics

We have isolated a unique fragment of the HLA-DR alpha gene and probed human genomic DNA at low stringency to search for homologous sequences. A minimum of six non-polymorphic cross-hybridizing high molecular weight fragments were found in all DNAs examined. In order to obtain molecular clones of these cross-hybridizing fragments, we constructed lambda and cosmid libraries of human DNA and screened them at low stringency with the HLA-DR alpha gene specific subclone. We have isolated clones corresponding to each of the six fragments and, in this paper, describe those which contain the gene encoding HLA-SB(DP) alpha.

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