Chromosomal orientation of the lambda light chain locus: Vλ is proximal to Cλ in 22q11 | Zendy

Beverly S. Emanuel | Zendy; Linda A. Cannizzaro | Zendy; I T Magrath | Zendy; Yoshihide Tsujimoto | Zendy; Peter C. Nowell̀ | Zendy; Carlo M. Croce | Zendy

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Chromosomal orientation of the lambda light chain locus: Vλ is proximal to Cλ in 22q11

Author(s) -

Beverly S. Emanuel,

Linda A. Cannizzaro,

I T Magrath,

Yoshihide Tsujimoto,

Peter C. Nowell̀,

Carlo M. Croce

Publication year - 1985

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/13.2.381

Subject(s) - biology , locus (genetics) , lambda , genetics , microbiology and biotechnology , gene , optics , physics

We have demonstrated that the chromosomal breakpoint at 22q11 of a Burkitt lymphoma cell line (PA682) with an 8;22 translocation interrupts the variable region of the lambda light chain locus. In these cells, all of the C lambda and some V lambda sequences translocate to the 8q+ chromosome whereas some V lambda sequences remain on the 22q-. These results indicate that the lambda light chain locus on the long arm of chromosome 22 is oriented such that V lambda is proximal to C lambda.

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