Computer programs used to aid in the selection of DNA hybridization probes | Zendy

Robert E. Raupach | Zendy

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Computer programs used to aid in the selection of DNA hybridization probes

Author(s) -

Robert E. Raupach

Publication year - 1984

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/12.1part2.833

Subject(s) - biology , hybridization probe , dna , selection (genetic algorithm) , nucleic acid thermodynamics , sequence (biology) , computational biology , dna sequencing , amino acid , messenger rna , in situ hybridization , dna–dna hybridization , genetics , base sequence , microbiology and biotechnology , gene , computer science , artificial intelligence

This paper describes a package of three programs which used together aid in selecting the best possible sequence to be used as a DNA hybridization probe. This system searches an amino acid sequence for four adjacent amino acids with the fewest possible corresponding mRNA sequences, calculates their probability of occurrence, and locates the positions of wobbles and mismatches between the DNA hybridization probe and the possible mRNA sequences.

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