Open AccessGraphic methods to determine the function of nucleic acid sequences
Author(s) -
Rodger Staden
Publication year - 1984
Publication title -
nucleic acids research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 9.008
H-Index - 537
eISSN - 1362-4954
pISSN - 0305-1048
DOI - 10.1093/nar/12.1part2.521
Subject(s) - biology , computational biology , nucleic acid , coding (social sciences) , sequence (biology) , gene , graphics , computer graphics , transfer rna , genetics , simple (philosophy) , conserved sequence , dna , function (biology) , computer science , peptide sequence , rna , data mining , mathematics , computer graphics (images) , philosophy , statistics , epistemology
We describe an interactive computer program (ANALYSEQ) that is used from a simple graphics terminal. The main purpose of the program is to determine the function of nucleic acid sequences but it also offers the simpler listing, searching and counting options. It contains methods to locate genes by looking for the effects that coding for a protein has on the coding sequence, to locate tRNA genes by looking for secondary structure and conserved bases, and methods to locate signals such as promoters. Techniques to identify unusual regions of sequence and to search for potential Z DNA-forming regions are also included. Most of the routines produce graphical output which gives ease of interpretation and allows superposition of several independent forms of analysis.
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