Post-transcriptional regulation of glyceraldehyde-3-phosphate-dehydrogenase gene expression in rat tissues | Zendy

Marc Piechaczyk | Zendy; Jean Marie Blanchard | Zendy; L. Marty | Zendy; Christian Dani | Zendy; F. Panabières | Zendy; Sanaa EL SABOUTY | Zendy; Philippe Fort | Zendy; Ph. Jeanteur | Zendy

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Post-transcriptional regulation of glyceraldehyde-3-phosphate-dehydrogenase gene expression in rat tissues

Author(s) -

Marc Piechaczyk,

Jean Marie Blanchard,

L. Marty,

Christian Dani,

F. Panabières,

Sanaa EL SABOUTY,

Philippe Fort,

Ph. Jeanteur

Publication year - 1984

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/12.18.6951

Subject(s) - glyceraldehyde 3 phosphate dehydrogenase , biology , microbiology and biotechnology , complementary dna , gene expression , gene , dehydrogenase , messenger rna , transcription (linguistics) , coding region , glyceraldehyde , enzyme , biochemistry , linguistics , philosophy

We have isolated and identified cDNA clones containing part of the coding sequence for rat glyceraldehyde-3-phosphate-dehydrogenase (GAPDH, E.C. 1.2.1.12). By using one of these clones as a probe, we have shown that: i) the abundance of GAPDH mRNA is different in various tissues of the adult rat and in good correlation with the abundance of the enzyme; ii) the transcription rates are quite similar in all tissues tested. We therefore conclude that the tissue-specific differential GAPDH gene expression is regulated by adjusting the abundance of its mRNA at the post-transcriptional level.

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