On the statistical assessment of similarities in DNA sequences | Zendy

J. Reich | Zendy; Heinz Drabsch | Zendy; Astrid Däumler | Zendy

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On the statistical assessment of similarities in DNA sequences

Author(s) -

J. Reich,

Heinz Drabsch,

Astrid Däumler

Publication year - 1984

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/12.13.5529

Subject(s) - biology , similarity (geometry) , dna , base pair , coincidence , simple (philosophy) , statistics , genetics , base (topology) , statistical analysis , standard deviation , computational biology , mathematics , statistical physics , artificial intelligence , computer science , physics , medicine , mathematical analysis , philosophy , alternative medicine , epistemology , pathology , image (mathematics)

The statistical behavior of the similarity score for unrelated DNA sequences calculated as letter-by-letter comparison or from various forms of optimal alignment was studied. It was found that natural DNA-sequences from a data base and true random sequences show the same statistical behavior in terms of such scores. This makes it possible to adopt a simple criterion for the rejection of fortuitous similarity. It is based on the mean and standard deviation of chance scores whose expected values, depending on chain length, gap penalty and probability of letter coincidence, may be calculated from formulae given in the paper.

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