Homology maps of theDrosophilaα-tubulin gene family: one of the four genes is different
Author(s) -
Howard J. Baum,
Yehudah Livneh,
Pieter C. Wensink
Publication year - 1983
Publication title -
nucleic acids research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 9.008
H-Index - 537
eISSN - 1362-4954
pISSN - 0305-1048
DOI - 10.1093/nar/11.16.5569
Subject(s) - biology , homology (biology) , gene , genetics , intron , drosophila melanogaster , exon , microbiology and biotechnology
We describe the intron-exon structure of and the homology among the four alpha-tubulin genes of Drosophila melanogaster. Three of the genes share a highly conserved 1.3 kb sequence which corresponds to most of the RNA complementary portion of the genes. The fourth gene is different. Its 5' half has weak homology and its 3' half has moderate homology to the other three genes. The homology maps were first determined by electron microscopy of heteroduplexes between pairs of genes. Higher resolution maps were then obtained by gel analysis of heteroduplexes that had been digested with S1 nuclease.
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